[HTML][HTML] Osteoclast differentiation is impaired in the absence of inhibitor of κB kinase α
ML Chaisson, DG Branstetter, JM Derry… - Journal of Biological …, 2004 - ASBMB
Signaling through the receptor activator of nuclear factor κB (RANK) is required for both
osteoclast differentiation and mammary gland development, yet the extent to which RANK
utilizes similar signaling pathways in these tissues remains unclear. Mice expressing a
kinase-inactive form of the inhibitor of κB kinase α (IKKα) have mammary gland defects
similar to those of RANK-null mice yet have apparently normal osteoclast function. Because
mice that completely lack IKKα have severe skin and skeletal defects that are not associated …
osteoclast differentiation and mammary gland development, yet the extent to which RANK
utilizes similar signaling pathways in these tissues remains unclear. Mice expressing a
kinase-inactive form of the inhibitor of κB kinase α (IKKα) have mammary gland defects
similar to those of RANK-null mice yet have apparently normal osteoclast function. Because
mice that completely lack IKKα have severe skin and skeletal defects that are not associated …