[HTML][HTML] Epidermal growth factor receptor activation differentially regulates claudin expression and enhances transepithelial resistance in Madin-Darby canine kidney …
Tight junctions (TJs) are the most apical cell-cell junctions, and claudins, the recently
identified TJ proteins, are critical for maintaining cell-cell adhesion in epithelial cell sheets.
Based on their in vivo distribution and the results of overexpression studies, certain claudins,
including claudin-1 and-4, are postulated to increase, whereas other claudins, especially
claudin-2, are postulated to decrease the overall transcellular resistance. The overall ratio
among claudins expressed in a cell/tissue has been hypothesized to define the complexity …
identified TJ proteins, are critical for maintaining cell-cell adhesion in epithelial cell sheets.
Based on their in vivo distribution and the results of overexpression studies, certain claudins,
including claudin-1 and-4, are postulated to increase, whereas other claudins, especially
claudin-2, are postulated to decrease the overall transcellular resistance. The overall ratio
among claudins expressed in a cell/tissue has been hypothesized to define the complexity …
