Myeloma proteins as tumor-specific transplantation antigens
RG Lynch, RJ Graff, S Sirisinha… - Proceedings of the …, 1972 - National Acad Sciences
RG Lynch, RJ Graff, S Sirisinha, ES Simms, HN Eisen
Proceedings of the National Academy of Sciences, 1972•National Acad SciencesBALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the
individually specific (“idiotypic”) determinants of these proteins and suppressed growth of
the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant
MOPC-315 tumors that produce only the light chain of protein 315 grew in several of the
mice immunized with this protein, probably because the anti-idiotypic immune response
selects against those myeloma cells that form the intact myeloma protein.
individually specific (“idiotypic”) determinants of these proteins and suppressed growth of
the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant
MOPC-315 tumors that produce only the light chain of protein 315 grew in several of the
mice immunized with this protein, probably because the anti-idiotypic immune response
selects against those myeloma cells that form the intact myeloma protein.
BALB/c mice immunized with myeloma proteins 315 or 460 made antibodies to the individually specific (“idiotypic”) determinants of these proteins and suppressed growth of the corresponding transplanted tumor cells (MOPC-315 or MOPC-460). Stable, variant MOPC-315 tumors that produce only the light chain of protein 315 grew in several of the mice immunized with this protein, probably because the anti-idiotypic immune response selects against those myeloma cells that form the intact myeloma protein.
National Acad Sciences