Apolipoprotein B metabolism and the distribution of VLDL and LDL subfractions
CJ Packard, T Demant, JP Stewart, D Bedford… - Journal of lipid …, 2000 - ASBMB
Apolipoprotein B (apoB) metabolism was investigated in 20 men with plasma triglyceride
0.66–2.40 mmol/l and plasma cholesterol 3.95–6.95 mmol/l. Kinetics of VLDL 1 (S f 60–400),
VLDL 2 (S f 20–60), IDL (S f 12–20), and LDL (S f 0–12) apoB were analyzed using a
trideuterated leucine tracer and a multicompartmental model which allowed input into each
fraction. VLDL 1 apoB production varied widely (from 5.4 to 26.6 mg/kg/d) as did VLDL 2
apoB production (from 0.18 to 8.4 mg/kg/d) but the two were not correlated. IDL plus LDL …
0.66–2.40 mmol/l and plasma cholesterol 3.95–6.95 mmol/l. Kinetics of VLDL 1 (S f 60–400),
VLDL 2 (S f 20–60), IDL (S f 12–20), and LDL (S f 0–12) apoB were analyzed using a
trideuterated leucine tracer and a multicompartmental model which allowed input into each
fraction. VLDL 1 apoB production varied widely (from 5.4 to 26.6 mg/kg/d) as did VLDL 2
apoB production (from 0.18 to 8.4 mg/kg/d) but the two were not correlated. IDL plus LDL …
