[HTML][HTML] Copper induces the assembly of a multiprotein aggregate implicated in the release of fibroblast growth factor 1 in response to stress
Fibroblast growth factor (FGF) 1 is known to be released in response to stress conditions as
a component of a multiprotein aggregate containing the p40 extravescicular domain of p65
synaptotagmin (Syt) 1 and S100A13. Since FGF1 is a Cu 2+-binding protein and Cu 2+ is
known to induce its dimerization, we evaluated the capacity of recombinant FGF1, p40 Syt1,
and S100A13 to interact in a cell-free system and the role of Cu 2+ in this interaction. We
report that FGF1, p40 Syt1, and S100A13 are able to bind Cu 2+ with similar affinity and to …
a component of a multiprotein aggregate containing the p40 extravescicular domain of p65
synaptotagmin (Syt) 1 and S100A13. Since FGF1 is a Cu 2+-binding protein and Cu 2+ is
known to induce its dimerization, we evaluated the capacity of recombinant FGF1, p40 Syt1,
and S100A13 to interact in a cell-free system and the role of Cu 2+ in this interaction. We
report that FGF1, p40 Syt1, and S100A13 are able to bind Cu 2+ with similar affinity and to …
