Effect of erythromycin on matrix metalloproteinase-9 and cell migration
N Hashimoto, T Kawabe, T Hara, K Imaizumi… - Journal of Laboratory …, 2001 - Elsevier
Erythromycin (EM) has an anti-inflammatory effect that may account for its clinical benefit in
the treatment of chronic inflammatory diseases such as diffuse panbronchiolitis. To
investigate the mechanism of this anti-inflammatory effect, we studied the relationship
between the concentration of EM and matrix metalloproteinase-9 (MMP-9) activity, which is
important in cell migration. We showed that EM suppressed the gelatinolytic activity of U937
cell–derived MMP-9 by using gelatin zymography, showed that expressions of MMP-9 …
the treatment of chronic inflammatory diseases such as diffuse panbronchiolitis. To
investigate the mechanism of this anti-inflammatory effect, we studied the relationship
between the concentration of EM and matrix metalloproteinase-9 (MMP-9) activity, which is
important in cell migration. We showed that EM suppressed the gelatinolytic activity of U937
cell–derived MMP-9 by using gelatin zymography, showed that expressions of MMP-9 …