[PDF][PDF] The NADPH oxidase inhibitors iodonium diphenyl and cadmium sulphate inhibit hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries
RD Jones, JS Thompson, AH Morice - Physiological Research, 2000 - biomed.cas.cz
Summary «Interest surrounds the role of an NADPH oxidase-like enzyme in hypoxic
pulmonary vasoconstriction (HPV). We have studied the effects of the NADPH oxidase
inhibitors iodonium diphenyl (ID) and cadmium sulphate (CdSO) upon HPV of isolated rat
pulmonary arteries (n= 73, internal diameter 545t23 pm). Vessels were preconstricted with
prostaglandin F,(PGF, 0.5 or 5 pM) prior to a hypoxic challenge. ID (10 or 50 pM),
CdSO,(100 pM) or vehicle (50 ul) was added for 30 min before re-exposure to PGF, and …
pulmonary vasoconstriction (HPV). We have studied the effects of the NADPH oxidase
inhibitors iodonium diphenyl (ID) and cadmium sulphate (CdSO) upon HPV of isolated rat
pulmonary arteries (n= 73, internal diameter 545t23 pm). Vessels were preconstricted with
prostaglandin F,(PGF, 0.5 or 5 pM) prior to a hypoxic challenge. ID (10 or 50 pM),
CdSO,(100 pM) or vehicle (50 ul) was added for 30 min before re-exposure to PGF, and …
