Annexin V inhibits phosphatidylserine-induced intrauterine growth restriction in mice
M Sugimura, T Kobayashi, F Shu, N Kanayama… - Placenta, 1999 - Elsevier
To investigate the role of phosphatidylserine (PS) derived from the activated platelets in
placental circulation, we established an artificial PS-induced intrauterine growth restriction
(IUGR) model in mice and examined whether annexin V, a PS-binding anticoagulant
protein, could prevent the development of IUGR in the animal experiments. The ICR mice
were injected in the tail vein on days 8, 11 and 14 of pregnancy with filtered PS/
phosphatidylcholine (PC) microvesicles (< 0.3 μm in maximal diameter). The microvesicles …
placental circulation, we established an artificial PS-induced intrauterine growth restriction
(IUGR) model in mice and examined whether annexin V, a PS-binding anticoagulant
protein, could prevent the development of IUGR in the animal experiments. The ICR mice
were injected in the tail vein on days 8, 11 and 14 of pregnancy with filtered PS/
phosphatidylcholine (PC) microvesicles (< 0.3 μm in maximal diameter). The microvesicles …
