Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway: divergence from downstream CT-1 signals …
Z Sheng, K Knowlton, J Chen, M Hoshijima… - Journal of biological …, 1997 - ASBMB
Cardiac myocyte survival is of central importance in the maintenance of the function of heart,
as well as in the development of a variety of cardiac diseases. To understand the molecular
mechanisms that govern this function, we characterized apoptosis in cardiac muscle cells
following serum deprivation. Cardiotrophin 1 (CT-1), a potent cardiac survival factor (Sheng,
Z., Pennica, D., Wood, WI, and Chien, KR (1996) Development (Camb.) 122, 419-428), is
capable of inhibiting apoptosis in cardiac myocytes. To explore the potential downstream …
as well as in the development of a variety of cardiac diseases. To understand the molecular
mechanisms that govern this function, we characterized apoptosis in cardiac muscle cells
following serum deprivation. Cardiotrophin 1 (CT-1), a potent cardiac survival factor (Sheng,
Z., Pennica, D., Wood, WI, and Chien, KR (1996) Development (Camb.) 122, 419-428), is
capable of inhibiting apoptosis in cardiac myocytes. To explore the potential downstream …
