[HTML][HTML] Characterization of a novel mammalian RGS protein that binds to Gα proteins and inhibits pheromone signaling in yeast
Genetic studies of molecules that negatively regulate G-coupled receptor functions have led
to the identification of a large gene family with an evolutionarily conserved domain, termed
the RGS domain. It is now understood that RGS proteins serve as GTPase-activating
proteins for subfamilies of the heterotrimeric G-proteins. We have isolated from mouse
pituitary a full-length cDNA clone encoding a novel member of the RGS protein family,
termed RGS16, as well as the full-length cDNA of mRGS5 and mRGS2. Tissue distribution …
to the identification of a large gene family with an evolutionarily conserved domain, termed
the RGS domain. It is now understood that RGS proteins serve as GTPase-activating
proteins for subfamilies of the heterotrimeric G-proteins. We have isolated from mouse
pituitary a full-length cDNA clone encoding a novel member of the RGS protein family,
termed RGS16, as well as the full-length cDNA of mRGS5 and mRGS2. Tissue distribution …