[HTML][HTML] Release of leukotriene A4 versus leukotriene B4 from human polymorphonuclear leukocytes

A Sala, M Bolla, S Zarini, R Müller-Peddinghaus… - Journal of Biological …, 1996 - ASBMB
The reactive intermediate formed by 5-lipoxygenase metabolism of arachidonic acid,
leukotriene A 4, is known to be released from cells and subsequently taken up by other cells
for biochemical processing. The objective of this study was to determine the relative amount
of leukotriene A 4 synthesized by human polymorphonuclear leukocytes (PMNL) that is
available for transcellular biosynthetic processes. This was accomplished by diluting cell
suspensions and measuring the relative amounts of enzymatic versus nonenzymatic …