[HTML][HTML] Series Introduction: Replication-selective microbiological agents: fighting cancer with targeted germ warfare
DH Kirn - The Journal of clinical investigation, 2000 - Am Soc Clin Investig
DH Kirn
The Journal of clinical investigation, 2000•Am Soc Clin InvestigElectron micrograph of a squamous carcinoma cell from a patient following intratumoral
injection with ONYX-015. This engineered strain of adenovirus replicates selectively in
tumor cells and causes tumor-specific cytotoxicity. The higher magnification image, shown at
the right, demonstrates that adenovirus particles form large arrays within the nucleus of
infected tumor cells.
injection with ONYX-015. This engineered strain of adenovirus replicates selectively in
tumor cells and causes tumor-specific cytotoxicity. The higher magnification image, shown at
the right, demonstrates that adenovirus particles form large arrays within the nucleus of
infected tumor cells.
Electron micrograph of a squamous carcinoma cell from a patient following intratumoral injection with ONYX-015. This engineered strain of adenovirus replicates selectively in tumor cells and causes tumor-specific cytotoxicity. The higher magnification image, shown at the right, demonstrates that adenovirus particles form large arrays within the nucleus of infected tumor cells.
The Journal of Clinical Investigation