[HTML][HTML] The γ134. 5 protein of herpes simplex virus 1 has the structural and functional attributes of a protein phosphatase 1 regulatory subunit and is present in a high …
B He, M Gross, B Roizman - Journal of Biological Chemistry, 1998 - ASBMB
The carboxyl-terminal domain of the γ 1 34.5 protein of the herpes simplex virus 1 binds to
protein phosphatase 1α (PP1) and is required to prevent the shut-off of protein synthesis
resulting from phosphorylation of the α subunit of eIF-2 by the double-stranded RNA-
activated protein kinase. The corresponding domain of the conserved GADD34 protein
homologous to γ 1 34.5 functionally substitutes for γ 1 34.5. This report shows that γ 1 34.5
and PP1 form a complex in the infected cells, that fractions containing this complex …
protein phosphatase 1α (PP1) and is required to prevent the shut-off of protein synthesis
resulting from phosphorylation of the α subunit of eIF-2 by the double-stranded RNA-
activated protein kinase. The corresponding domain of the conserved GADD34 protein
homologous to γ 1 34.5 functionally substitutes for γ 1 34.5. This report shows that γ 1 34.5
and PP1 form a complex in the infected cells, that fractions containing this complex …
