Preventive effects of transdermal 17β-estradiol on osteoporotic changes after surgical menopause: a two-year placebo-controlled trial
CS Field, SJ Ory, HW Wahner, RR Herrmann… - American journal of …, 1993 - Elsevier
Objective: The purpose of our study was to evaluate the effects of three dosages of
transdermally administered 17 β-estradiol on markers of bone loss in women who had
recently undergone surgical menopause. Study Design: This was a 2-year, randomized,
double-blind, placebo-controlled study that reviewed 127 women stratified by age.
Biochemical indicators of bone metabolism in urine and serum were periodically assessed,
as was bone mineral content of the lumbar spine and radius. Statistical analysis examined …
transdermally administered 17 β-estradiol on markers of bone loss in women who had
recently undergone surgical menopause. Study Design: This was a 2-year, randomized,
double-blind, placebo-controlled study that reviewed 127 women stratified by age.
Biochemical indicators of bone metabolism in urine and serum were periodically assessed,
as was bone mineral content of the lumbar spine and radius. Statistical analysis examined …